Which type of tumor is associated with multiple endocrine neoplasia, type 2B?

Multiple endocrine neoplasia, type 2B (MEN 2B), is a hereditary syndrome characterized by a specific set of tumors that arise in various endocrine glands. The condition is associated with mutations in the RET proto-oncogene, leading to the development of specific tumor types.

Pheochromocytoma, originating from the adrenal medulla, is a common manifestation in individuals with MEN 2B. These tumors secrete catecholamines, which can lead to symptoms like hypertension, palpitations, and sweating. The presence of pheochromocytomas in MEN 2B patients is not just incidental; these tumors are part of the diagnostic criteria for this syndrome.

In contrast, the other tumor types listed do not hold the same association with MEN 2B. Ovarian tumors are not a feature of MEN 2B, though ovarian tumors may occur in different contexts. Pituitary tumors are more commonly associated with other syndromes, such as MEN 1. Thyroid tumors, specifically medullary thyroid carcinoma, are associated with MEN 2A, but they do occur in MEN 2B as well; however, the defining tumor of MEN 2B is the pheochromocytoma because of its