Which type of Dentinogenesis Imperfecta is more common in the Brandywine population?

Dentinogenesis Imperfecta (DI) is a genetic disorder affecting dentin formation, leading to discolored and brittle teeth. The Brandywine population, specifically noted for its unique genetic traits, has a higher prevalence of Type III Dentinogenesis Imperfecta.

Type III DI is also referred to as Brandywine type because it was first identified in this specific population. This type is characterized by a distinctive blue-gray color of the teeth and a significant amount of enamel loss, resulting in a risk of tooth fractures and pulp exposure. The genetic basis of Type III DI is linked to a mutation in the dentin sialophosphoprotein (DSPP) gene, which is crucial for the proper development of dentin.

In contrast, Types I and II are associated with specific syndromes such as Osteogenesis Imperfecta and are generally found in broader populations rather than being localized to a specific group like the Brandywine population. Type IV is also associated with a different trait pattern and does not have the same prevalence in this population. Thus, the connection between Type III DI and the Brandywine population highlights its unique genetic heritage, making it the most common type found there.