Which syndrome results from premature closure of cranial sutures?

Apert Syndrome is characterized by the premature fusion of cranial sutures, a condition known as craniosynostosis. This early fusion leads to abnormal head shapes and can affect brain development due to restricted space as the brain grows. The other options listed do not primarily involve cranial suture closure or craniosynostosis as a defining feature of their syndromes. Down Syndrome is primarily associated with a chromosomal abnormality, Turner Syndrome relates to the absence of part or all of a second sex chromosome, and Nevoid Basal Cell Carcinoma Syndrome is linked to genetic mutations affecting skin and developmental anomalies, none of which are primarily defined by cranial suture fusion like Apert Syndrome.