Which syndrome is characterized by intestinal polyps with high malignancy potential?

Gardner Syndrome is characterized by the development of intestinal polyps that carry a high risk of malignancy. This genetic condition is a subtype of familial adenomatous polyposis (FAP) and is associated with the formation of numerous adenomatous polyps in the colon and rectum, which can progress to colorectal cancer if left untreated. In addition to the intestinal polyps, individuals with Gardner Syndrome may also exhibit extracolonic manifestations such as osteomas, epidermoid cysts, and fibromas, which further highlight the syndrome's broad impact on the body.

The high malignancy potential of the intestinal polyps is a critical aspect of this syndrome, necessitating regular surveillance and management to reduce cancer risk. Early intervention, which often includes prophylactic colectomy, is important for preventing cancer development in affected individuals. Understanding the malignancy risk associated with Gardner Syndrome is essential in clinical practice, particularly for guiding patient monitoring and treatment strategies.