Which of the following is NOT a systemic disease associated with chronic periodontitis?

Chronic periodontitis is primarily associated with several systemic conditions that can influence or complicate periodontal disease. Among the diseases listed, cyclic neutropenia, agranulocytosis, and Down syndrome have established connections to periodontal health.

Cyclic neutropenia is a disorder characterized by periodic drops in the number of neutrophils, leading to increased susceptibility to infections, including periodontal infections. Similarly, agranulocytosis, which involves a severe reduction in white blood cells, can lead to compromised immune responses and heighten periodontal problems.

Down syndrome has also been linked to periodontal disease due to genetic factors that can cause immunosuppression and other systemic issues that affect oral health.

On the other hand, chronic migraine does not have a recognized association with chronic periodontitis. Migraines are primarily neurological disorders and do not typically impact periodontal health or the inflammatory processes involved in periodontal disease. Thus, it is the only condition listed that does not have a systemic connection to chronic periodontitis.