Which of the following conditions are characterized by cafe au lait spots?

Cafe au lait spots are pigmented skin lesions characterized by a light brown color that resembles the beverage they are named after. These spots are particularly associated with certain genetic conditions.

McCune-Albright syndrome is one such condition that prominently features cafe au lait spots among its clinical manifestations. This genetic disorder results from a mutation affecting the G protein signaling pathway, leading to various endocrine and skeletal abnormalities. The cafe au lait spots seen in this syndrome typically appear during early childhood and may increase in number over time. The occurrence of these skin lesions, along with other features such as precocious puberty and fibrous dysplasia of bone, makes McCune-Albright syndrome recognizable.

The other conditions mentioned do not commonly lead to the development of cafe au lait spots. Diabetes Mellitus, while it has a range of dermatological manifestations, does not typically present with these specific spots. Lupus Erythematosus may cause skin rashes and lesions, but cafe au lait spots are not characteristic of this autoimmune condition. Chronic Fatigue Syndrome is primarily a chronic condition characterized by extreme fatigue and does not have a direct association with the presence of cafe au lait spots.

Thus, the connection of cafe au lait spots to McCune-Albright syndrome is a key