Which condition is NOT commonly associated with cafe-au-lait spots?

Cafe-au-lait spots are flat, pigmented birthmarks that can appear on the skin and are associated with several genetic conditions. Among the listed conditions, Marfan syndrome is NOT commonly associated with cafe-au-lait spots.

Tuberous sclerosis, McCune-Albright syndrome, and Neurofibromatosis type 1, on the other hand, are all conditions where cafe-au-lait spots are frequently observed. Neurofibromatosis type 1 typically presents with multiple cafe-au-lait spots as one of its hallmark signs. Similarly, Tuberous sclerosis can lead to various skin manifestations, including these spots, and McCune-Albright syndrome is characterized by both cafe-au-lait spots and endocrine abnormalities.

Marfan syndrome primarily affects connective tissues and is associated with features such as tall stature, long limbs, and heart and eye problems, but not with the specific skin manifestations like cafe-au-lait spots. Understanding these associations helps in the clinical differentiation and diagnosis of various genetic syndromes.