Which antibiotic must be taken on an empty stomach due to degradation by stomach enzymes?

Penicillin V is an antibiotic that is often prescribed to be taken on an empty stomach because food can significantly affect its absorption. When taken in the presence of food, the gastric enzymes can break down the medication, leading to decreased effectiveness. Taking it on an empty stomach helps ensure that the antibiotic is absorbed properly and can exert its therapeutic effects efficiently.

In contrast, other antibiotics listed may have different absorption characteristics. For example, amoxicillin can typically be taken with or without food, as it does not suffer from the same degradation issues in the stomach. Ciprofloxacin and doxycycline may also have considerations regarding food intake, but they do not require an empty stomach for optimal absorption like Penicillin V does. Understanding the specific absorption requirements for various antibiotics is crucial for healthcare providers to ensure effective treatment.