What virus is Burkitt's Lymphoma closely associated with?

Burkitt's Lymphoma is closely associated with the Epstein-Barr Virus (EBV), a member of the herpesvirus family. EBV is known for its role in various lymphoproliferative disorders, including Burkitt's Lymphoma, which is characterized by the rapid growth of tumors, primarily in the lymphatic system. The association arises because the virus can lead to the activation of oncogenes and the proliferation of B lymphocytes, which contributes to the development of lymphomas.

EBV is particularly known for its connection with the endemic form of Burkitt's Lymphoma, commonly found in regions of Africa where malaria is prevalent. This endemic form is characterized by a specific chromosomal translocation involving the MYC gene, which is often driven by EBV infection. The presence of EBV in the tumor cells is one of the key features that help in the diagnosis of this type of lymphoma.

In summary, the association between Burkitt's Lymphoma and the Epstein-Barr Virus highlights the significance of EBV in oncogenesis and its impact on B cell proliferation, leading to the development of this aggressive form of lymphoma.