What syndrome results in melanin hyperpigmentation of the lips and polyposis of the small intestine?

Peutz-Jeghers syndrome is characterized by several distinct clinical features, including melanin hyperpigmentation of the lips and a propensity for the development of hamartomatous polyps in the gastrointestinal tract, particularly the small intestine.

The melanin pigmentation typically appears as dark spots or freckles on the mucous membranes, including the lips, and can also be seen on the skin. This pigmentation is an important diagnostic marker of the syndrome.

In addition to the pigmentation, individuals with Peutz-Jeghers syndrome have an increased risk of developing various types of cancer due to the genetic mutations associated with the condition. The polyps that develop in the small intestine can lead to intestinal obstructions or other complications but are generally non-cancerous.

Understanding these hallmark features helps to differentiate Peutz-Jeghers syndrome from other conditions, as the presence of both lip pigmentation and small intestine polyposis is distinctive to this syndrome.