What layer do neural crest cells develop from?

Neural crest cells originate from the ectoderm, which is one of the three primary germ layers formed during embryonic development. Specifically, these cells arise from the neuroectoderm when the neural tube forms, which is part of the ectoderm.

Neural crest cells have a unique developmental pathway where they migrate from their origin to various locations in the body, giving rise to a wide range of structures, including neurons of the peripheral nervous system, pigment cells, and elements of facial cartilage. This ability to migrate and differentiate into multiple cell types distinguishes neural crest cells from other cell types derived from the same ectodermal layer.

Understanding the role of the ectoderm in the development of neural crest cells highlights the complexity of cell lineage and differentiation during early embryonic development.